臍帶血能治療進行性肌營養不良，很急，謝謝！
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濟南市106醫院神經外科王明席：
有希望：請看此文章，
J Transl Med. 2009 Jan 14;7:6.
Stem cells from umbilical cord blood do have myogenic potential, with and without differentiation induction in vitro.
Jazedje T, Secco M, Vieira NM, Zucconi E, Gollop TR, Vainzof M, Zatz M.
Department of Biology, Human Genome Research Center, São Paulo, Brazil. mayazatz@usp.br
Abstract
The dystrophin gene, located at Xp21, codifies dystrophin, which is part of a protein complex responsible for the membrane stability of muscle cells. Its absence on muscle causes Duchenne Muscular Dystrophy (DMD), a severe disorder, while a defect of muscle dystrophin causes Becker Muscular Dystrophy (DMB), a milder disease. The replacement of the defective muscle through stem cells transplantation is a possible future treatment for these patients. Our objective was to analyze the potential of CD34+ stem cells from umbilical cord blood to differentiate in muscle cells and express dystrophin, in vitro. Protein expression was analyzed by Immunofluorescence, Western Blotting (WB) and Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). CD34+ stem cells and myoblasts from a DMD affected patient started to fuse with muscle cells immediately after co-cultures establishment. Differentiation in mature myotubes was observed after 15 days and dystrophin-positive regions were detected through Immunofluorescence analysis. However, WB or RT-PCR analysis did not detect the presence of normal dystrophin in co-cultures of CD34+ and DMD or DMB affected patients' muscle cells. In contrast, some CD34+ stem cells differentiated in dystrophin producers' muscle cells, what was observed by WB, reinforcing that this progenitor cell has the potential to originate muscle dystrophin in vitro, and not just in vivo like reported before.
1. 有家族史嗎-其他的任何親戚有類似的癥狀嗎？
2. 能把MRI、CT、肌電圖拍成照片、發過來嗎？
3. 我從事此類疾病的研究（華僑大學分子藥物研究所/分子藥物教育部工程研究中心 基因診斷、基因治療實驗室）：基因診斷、產前診斷（保證新生兒以后不患此病）；
4. 無有效治療措施。
5. 可將資料、片子壓縮后發到1470291264@QQ.COM,看后回復, 電話聯系：15336418991。
